Histone carbonylation occurs in proliferating cells
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چکیده
منابع مشابه
Histone carbonylation in vivo and in vitro.
Non-enzymic damage to nuclear proteins has potentially severe consequences for the maintenance of genomic integrity. Introduction of carbonyl groups into histones in vivo and in vitro was assessed by Western blot immunoassay and reductive incorporation of tritium from radiolabelled NaBH(4) (sodium borohydride). Histone H1 extracted from bovine thymus, liver and spleen was found to contain signi...
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Three clones containing vertebrate histone genes, two from chicken and one from human have been investigated. DNA from each recombinant within lambda Charon 4A has been strand-separated on agarose gels in the presence of poly r(UG). Southern transfer analysis with histone cDNA indicates that in each case transcription occurs from both strands. These results argue against the possibility of poly...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2012
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2012.01.022